Modern ethical perspectives toward the environment often emphasize the connection of humans to a broader biotic community. The full intimacy of this connectedness, however, is only now being revealed as scientific findings in developmental biology and genetics provide new insights into the importance of environmental interaction for the development of organisms. These insights are reshaping our understanding of how organism-environment interaction contributes to both consistency and variation in organism development, and leading to a new perspective whereby an “organism” is not (...) solely viewed as the adaptive product of evolutionary selection to an external environment over generations, but as continuously being constructed through systems of interactions that link an organism’s characteristics developmentally to the physical and social influences it experiences during life. This newfound emphasis on “interaction” leads to an interdependency whereby any change to an “environment” impacts the interacting “organism,” and an alteration to the “organism” eventually affects its “environment.” The causal reciprocity embedded within this organism-environment interdependency holds implications for our moral obligations to environments, given their compulsory role in shaping all organisms including ourselves. (shrink)

ABSTRACT Controlled human infection (CHI) models have been developed for numerous pathogens in order to better understand disease processes and accelerate drug and vaccine testing. In the past, some researchers conducted highly controversial CHIs with vulnerable populations, including children. Ethical frameworks for CHIs now recommend vulnerable populations be excluded because they cannot consent to high risk research. In this paper we argue that CHI studies span a wide spectrum of benefit and risk, and that some CHI studies may involve minimal (...) risk. The categorical exclusion of children from CHIs therefore departs from the standard approach to evaluating research risks, as international regulations and ethical guidance for pediatric research generally permit non‐beneficial research with low risks. The paradigm in research ethics has also shifted from focusing on protecting vulnerable participants to recognizing that inclusion can be important as a matter of justice, providing new reasons to question this default exclusion of children from CHIs. Recognizing that pediatric CHIs can raise complex ethical issues and are easy to sensationalize in ways that may threaten the public’s trust in research and sponsor institutions, we conclude by describing additional complexities that must be addressed before pediatric CHIs beyond licensed vaccine studies might be ethically acceptable. (shrink)

In the preceding article, Buchner and Wippich used a guessing-corrected, multinomial process-dissociation analysis to test whether a gender bias in fame judgments reported by Banaji and Greenwald was unconscious. In their two experiments, Buchner and Wippich found no evidence for unconscious mediation of this gender bias. Their conclusion can be questioned by noting that the gender difference in familiarity of previously seen names that Buchner and Wippich modeled was different from the gender difference in criterion for fame judgments reported by (...) Banaji and Greenwald, the assumptions of Buchner and Wippich's multinomial model excluded processes that are plausibly involved in the fame judgment task, and the constructs of Buchner and Wippich's model that corresponded most closely to Banaji and Greenwald's gender-bias interpretation were formulated so as to preclude the possibility of modeling that interpretation. Perhaps a more complex multinomial model can model the Banaji and Greenwald interpretation. (shrink)

Benacerraf’s 1965 multiple-reductions argument depends on what I call ‘deferential logicism’: his necessary condition for number-set identity is most plausible against a background Quineanism that allows autonomy of the natural number concept. Steinhart’s ‘folkist’ sufficient condition on number-set identity, by contrast, puts that autonomy at the center — but fails for not taking the folk perspective seriously enough. Learning from both sides, we explore new conditions on number-set identity, elaborating a suggestion from Wright.

Neo-Fregeans have been troubled by the Nuisance Principle, an abstraction principle that is consistent but not jointly satisfiable with the favored abstraction principle HP. We show that logically this situation persists if one looks at joint consistency rather than satisfiability: under a modest assumption about infinite concepts, NP is also inconsistent with HP.

The injective version of Cantor’s theorem appears in full second-order logic as the inconsistency of the abstraction principle, Frege’s Basic Law V (BLV), an inconsistency easily shown using Russell’s paradox. This incompatibility is akin to others—most notably that of a (Dedekind) infinite universe with the Nuisance Principle (NP) discussed by neo-Fregean philosophers of mathematics. This paper uses the Burali–Forti paradox to demonstrate this incompatibility, and another closely related, without appeal to principles related to the axiom of choice—a result hitherto unestablished. (...) It discusses both the general interest of this result, its interest to neo-Fregean philosophy of mathematics, and the potential significance of the Burali–Fortian method of proof. (shrink)

This article improves two existing theorems of interest to neologicist philosophers of mathematics. The first is a classification theorem due to Fine for equivalence relations between concepts definable in a well-behaved second-order logic. The improved theorem states that if an equivalence relation E is defined without nonlogical vocabulary, then the bicardinal slice of any equivalence class—those equinumerous elements of the equivalence class with equinumerous complements—can have one of only three profiles. The improvements to Fine’s theorem allow for an analysis of (...) the well-behaved models had by an abstraction principle, and this in turn leads to an improvement of Walsh and Ebels-Duggan’s relative categoricity theorem. (shrink)

The concept of selecting for a disability, and deafness in particular, has triggered a controversial and sometimes acrimonious debate between key stakeholders. Previous studies have concentrated on the views of the deaf and hard of hearing, health professionals and ethicists towards reproductive selection for deafness. This study, however, is the first of its kind examining the views of hearing children of deaf adults towards preimplantation genetic diagnosis and prenatal diagnosis to select for or against deafness. Hearing children of deaf adults (...) straddle both the deaf and hearing worlds, and this dual perspective makes them ideally placed to add to the academic discourse concerning the use of genetic selection for or against deafness. The study incorporated two complementary stages, using initial, semistructured interviews with key informants as a means to guide the subsequent development of an electronic survey, completed anonymously by 66 individuals. The participants shared many of the same views as deaf individuals in the D/deaf community. The similarities extended to their opinions regarding deafness not being a disability, their ambivalence towards having hearing or deaf children and their general disapproval of the use of genetic technologies to select either for or against deafness. (shrink)

This remarkable collection explores the legacy of Wittgenstein's work in contemporary American philosophy. The contributors (including several celebrated philosophers) take a variety of approaches to Wittgenstein; they discuss such topics as rule-following, realism about mathematics, the method of the Tractatus, the relation between style and content in Wittgenstein, and his distinction between sense and nonsense. Wittgenstein also is discussed in relation to subsequent philosophers such as Quine and Kripke.

Objects appear to fall into different sorts, each with their own criteria for identity. This raises the question of whether sorts overlap. Abstractionists about numbers—those who think natural numbers are objects characterized by abstraction principles—face an acute version of this problem. Many abstraction principles appear to characterize the natural numbers. If each abstraction principle determines its own sort, then there is no single subject-matter of arithmetic—there are too many numbers. That is, unless objects can belong to more than one sort. (...) But if there are multi-sorted objects, there should be cross-sortal identity principles for identifying objects across sorts. The going cross-sortal identity principle, ECIA2 of Cook and Ebert (2005), solves the problem of too many numbers. But, I argue, it does so at a high cost. I therefore propose a novel cross-sortal identity principle, based on embeddings of the induced models of abstracts developed by Walsh (2012). The new criterion matches ECIA2’s success, but offers interestingly different answers to the more controversial identifications made by ECIA2. (shrink)

A widespread perception is that carnivores are limited by the amount of prey that can be captured rather than their nutritional quality, and thus have no need to regulate macronutrient balance. Contrary to this view, recent laboratory studies show macronutrient‐specific food selection by both invertebrate and vertebrate predators, and in some cases also associated performance benefits. The question thus arises of whether wild predators might likewise feed selectively according to the macronutrient content of prey. Here we review laboratory studies demonstrating (...) the regulation of macronutrient intake by invertebrate and vertebrate predators, and address the question of whether this is likely to also occur in the wild. We conclude that it is highly likely that wild predators select prey or selectively feed on body parts according to their macronutrient composition, a possibility that could have significant implications for ecological and foraging theory, as well as applied wildlife conservation and management. (shrink)

This article engages in debates about the potential for aesthetics to be a positive, ethical, and moral frame for relating to the environment. Human‐environment relations are increasingly tied up with aesthetics. We problematize this trend by contending that aesthetics is an insufficient paradigm to motivate and shape environmentalism because it exceptionalizes some landscapes while devaluing others. This article uses four illustrative case studies to complicate aesthetic environmentalist frames. These case studies indicate that even when positive aesthetic qualities are deployed in (...) environmentalist advocacy, their usefulness is mitigated by a range of factors including: sensationalization, obfuscation, and further degradation. (shrink)

The sports media landscape has shifted to favor outlets with inside access to sports organizations, teams, and athletes. This study interviews 21 NFL in-house reporters working at 19 official team websites to determine how they view their roles as sports journalists, including ethical standards and shifts in media boundaries. Qualitative interviews uncovered that cultivating a positive team image and protecting the interests of stakeholders supersede the production of objective news stories, even from those who started their careers as external sports (...) reporters. Internal reporters are often conflicted with their roles in the sports media ecosystem. Additionally, interviews reveal their efforts to maintain a balancing act between the established ideals of journalism with the positive spin that accompanies public relations. The present study illuminates how such positions both mirror and diverge from the expectations typically placed within sports journalism, while offering fruitful avenues for subsequent scholarly investigation. (shrink)

A diagonal version of the strong reflection principle is introduced, along with fragments of this principle associated with arbitrary forcing classes. The relationships between the resulting principles and related principles, such as the corresponding forcing axioms and the corresponding fragments of the strong reflection principle, are analyzed, and consequences are presented. Some of these consequences are “exact” versions of diagonal stationary reflection principles of sets of ordinals. We also separate some of these diagonal strong reflection principles from related axioms.

When this work was first published in 1960, it immediately filled a void in Kantian scholarship. It was the first study entirely devoted to Kant's _Critique of Practical Reason_ and by far the most substantial commentary on it ever written. This landmark in Western philosophical literature remains an indispensable aid to a complete understanding of Kant's philosophy for students and scholars alike. This _Critique_ is the only writing in which Kant weaves his thoughts on practical reason into a unified argument. (...) Lewis White Beck offers a classic examination of this argument and expertly places it in the context of Kant's philosophy and of the moral philosophy of the eighteenth century. (shrink)

A crisis continues to brew within the pharmaceutical research and development (R&D) enterprise: productivity continues declining as costs rise, despite ongoing, often dramatic scientific and technical advances. To reverse this trend, we offer various suggestions for both the expansion and broader adoption of modeling and simulation (M&S) methods. We suggest strategies and scenarios intended to enable new M&S use cases that directly engage R&D knowledge generation and build actionable mechanistic insight, thereby opening the door to enhanced productivity. What M&S requirements (...) must be satisfied to access and open the door, and begin reversing the productivity decline? Can current methods and tools fulfill the requirements, or are new methods necessary? We draw on the relevant, recent literature to provide and explore answers. In so doing, we identify essential, key roles for agent-based and other methods. We assemble a list of requirements necessary for M&S to meet the diverse needs distilled from a collection of research, review, and opinion articles. We argue that to realize its full potential, M&S should be actualized within a larger information technology framework—a dynamic knowledge repository—wherein models of various types execute, evolve, and increase in accuracy over time. We offer some details of the issues that must be addressed for such a repository to accrue the capabilities needed to reverse the productivity decline. (shrink)

Nursing and nurses have become reliant on qualitative methods to understand the meaning of nursing care, and many nurse researchers use Heideggerian Interpretivist phenomenology approaches. Often these nurses are unaware of Martin Heidegger's role in the German National Socialist Party of the 1930s and his allegiance to fascist ideology. We ask: can a bad person have good ideas? In line with pragmatic thinkers such as Richard Rorty, we argue that instead of value judgements on people and their ideas, nurses should (...) consider ideas as a product of a historical/social and political time and space. In urging a critical political engagement, we argue for a Husserlian approach. In opposition to Heidegger's interpretivist phenomenology approach, in which the hegemony of the day is integral to the phenomena being studied, we propose that a more expressive, collaborative engagement using Husserlian descriptive phenomenology approach would serve better in encouraging a more critical engagement with how ideas are used by groups of people, how some groups might be advantaged and others disadvantaged. Our conclusion is that the separation of ideas from political and social context is dangerous, and nurses, including nurse researchers, must understand how their research ideas and methods influence and are influenced by political agendas. (shrink)

Navigating limits to confidentiality with adolescent clients can be ethically and professionally challenging. This study follows on from a previous quantitative survey of psychologists about confidentiality dilemmas with adolescents. The current study used qualitative methods to explore such dilemmas in greater depth. Twenty Australian psychologists were interviewed and asked to describe an ethically challenging past case. Cases were then used to facilitate discussion about the decision-making process and outcomes. Interviews were transcribed and analyzed using interpretive content and thematic analysis. Three (...) key findings are discussed. First, it is of little use to perceive confidentiality dilemmas as binary choices because psychologists described 5 distinct options. These can be conceptualized on a spectrum of varying degrees of client autonomy, ranging from “no disclosure” to “disclosure without the client’s knowledge or consent”. Second, confidentiality dilemmas often involve balancing multiple and conflicting risks regarding both immediate and future harm. Third, a range of strategies are employed by psychologists to minimize potential harms when disclosing information. These are primarily aimed at maintaining the therapeutic relationship and empowering clients. These findings and the case studies described provide a valuable resource for teaching and professional development. (shrink)

This paper outlines a first attempt to model the special constraints that arise in language processing in conversation, and to explore the implications such functional considerations may have on language typology and language change. In particular, we focus on processing pressures imposed by conversational turn-taking and their consequences for the cultural evolution of the structural properties of language. We present an agent-based model of cultural evolution where agents take turns at talk in conversation. When the start of planning for the (...) next turn is constrained by the position of the verb, the stable distribution of dominant word orders across languages evolves to match the actual distribution reasonably well. We suggest that the interface of cognition and interaction should be a more central part of the story of language evolution. (shrink)

“Tell me," Wittgenstein once asked a friend, "why do people always say, it was natural for man to assume that the sun went round the earth rather than that the earth was rotating?" His friend replied, "Well, obviously because it just looks as though the Sun is going round the Earth." Wittgenstein replied, "Well, what would it have looked like if it had looked as though the Earth was rotating?” What would it have looked like if we looked at all (...) sciences from the viewpoint of Wittgenstein’s philosophy? Wittgenstein is undoubtedly one of the most influential philosophers of the twentieth century. His complex body of work has been analysed by numerous scholars, from mathematicians and physicists, to philosophers, linguists, and beyond. This volume brings together some of his central perspectives as applied to the modern sciences and studies the influence they may have on the thought processes underlying science and on the world view it engenders. The contributions stem from leading scholars in philosophy, mathematics, physics, economics, psychology and human sciences; all of them have written in an accessible style that demands little specialist knowledge, whilst clearly portraying and discussing the deep issues at hand. (shrink)

Biological ontologies are used to organize, curate, and interpret the vast quantities of data arising from biological experiments. While this works well when using a single ontology, integrating multiple ontologies can be problematic, as they are developed independently, which can lead to incompatibilities. The Open Biological and Biomedical Ontologies Foundry was created to address this by facilitating the development, harmonization, application, and sharing of ontologies, guided by a set of overarching principles. One challenge in reaching these goals was that the (...) OBO principles were not originally encoded in a precise fashion, and interpretation was subjective. Here we show how we have addressed this by formally encoding the OBO principles as operational rules and implementing a suite of automated validation checks and a dashboard for objectively evaluating each ontology’s compliance with each principle. This entailed a substantial effort to curate metadata across all ontologies and to coordinate with individual stakeholders. We have applied these checks across the full OBO suite of ontologies, revealing areas where individual ontologies require changes to conform to our principles. Our work demonstrates how a sizable federated community can be organized and evaluated on objective criteria that help improve overall quality and interoperability, which is vital for the sustenance of the OBO project and towards the overall goals of making data FAIR. Competing Interest StatementThe authors have declared no competing interest. (shrink)

We present an annotated bibliography of peer reviewed scientific research highlighting the human health, animal welfare, and environmental risks associated with genetic modification. Risks associated with the expression of the transgenic material include concerns over resistance and non-target effects of crops expressing Bt toxins, consequences of herbicide use associated with genetically modified herbicide-tolerant plants, and transfer of gene expression from genetically modified crops through vertical and horizontal gene transfer. These risks are not connected to the technique of genetic modification as (...) such, but would be present for any conventionally produced crops with the same heritable traits. In contrast, other risks are a direct consequence of the method used in gene manipulation. These come about because of the unstable nature of the transgene and vectors used to insert it, and because of unpredictable interactions between the transgene and the host genome. The debate over the release of genetically modified organisms is not merely a scientific one; it encompasses economics, law, ethics, and policy. Any discussion on these levels does, however, need to be informed by sound science. We hope that the scientific references provided here will provide a useful starting point for further debate. (shrink)

Arthur Danto is the Johnsonian Professor Emeritus of Philosophy at Columbia University and the most influential philosopher of art in the last half century. As an art critic for The Nation for 25 years and frequent contributor to other widely read outlets such as the New York Review of Books, Danto also has become one of the most respected public intellectuals of his generation. He is the author of some two dozen important books, along with hundreds of articles and reviews (...) which have been the center of both controversy and discussion. In this volume Danto offers his intellectual autobiography and responds to essays by 27 of the keenest critics of his thought from the worlds of philosophy and the arts. The book includes 16 pages of color art reproductions. Danto is the author dozens of books on art, philosophy, the philosophy of art, and art criticism. He is a rare philosopher who is also a public intellectual. (shrink)

Variant Creutzfeldt–Jakob disease is a fatal, transmissible, neurodegenerative disorder for which there is currently no effective treatment. vCJD arose from the zoonotic spread of bovine spongiform encephalopathy. There is now compelling evidence for human to human transmission through blood transfusions from presymptomatic carriers and experts are warning that the real epidemic may be yet to come. Imperatives exist for the development of reliable, non-invasive presymptomatic diagnostic tests. Research into such tests is well advanced. In this article the ethical implications of (...) the availability of these tests are elaborated and comparisons drawn with predictive genetic testing for Huntington’s disease and screening for HIV. Paramount to considerations is the issue of whom to test, weighing up respect for personal autonomy against obligations to benefit and protect society. A paradigm is proposed similar to that used for HIV screening but with unique features: compulsory testing of all blood/organ donors and individuals undergoing surgery or invasive procedures who have a significant risk of disease transmission. (shrink)

The present theory leads to a set of subjective weights such that the utility of an uncertain alternative (gamble) is partitioned into three terms involving those weights—a conventional subjectively weighted utility function over pure consequences, a subjectively weighted value function over events, and a subjectively weighted function of the subjective weights. Under several assumptions, this becomes one of several standard utility representations, plus a weighted value function over events, plus an entropy term of the weights. In the finitely additive case, (...) the latter is the Shannon entropy; in all other cases it is entropy of degree not 1. The primary mathematical tool is the theory of inset entropy. (shrink)

Data from various settings suggest that there is an upper limit of about four on the number of individuals who can interact in spontaneous conversation. This limit appears to be a consequence of the mechanisms of speech production and detection. There appear to be no differences between men and women in this respect, other than those introduced by women’s lighter voices.

Critical care is in an emerging crisis of conflict between what individuals expect and the economic burden society and government are prepared to provide. The goal of critical care support is to prevent suffering and premature death by intensive therapy of reversible illnesses within a reasonable timeframe. Recently, it has become apparent that early support in an intensive care environment can improve patient outcomes. However, life support technology has advanced, allowing physicians to prolong life (and postpone death) in circumstances that (...) were not possible in the recent past. This has been recognized by not only the medical community, but also by society at large. One corollary may be that expectations for recovery from critical illness have also become extremely high. In addition, greater numbers of patients are dying in intensive care units after having receiving prolonged durations of life-sustaining therapy. Herein lies the emerging crisis – critical care therapy must be available in a timely fashion for those who require it urgently, yet its provision is largely dependent on a finite availability of both capital and human resources. Physicians are often placed in a troubling conflict of interest by pressures to use health resources prudently while also promoting the equitable and timely access to critical care therapy. In this commentary, these issues are broadly discussed from the perspective of the individual clinician as well as that of society as a whole. The intent is to generate dialogue on the dynamic between individual clinicians navigating the complexities of how and when to use critical care support in the context of end-of-life issues, the increasing demands placed on finite critical care capacity, and the reasonable expectations of society. (shrink)